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Week 1 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay pays 25-1

Seven months after profitable the Tremendous Bowl at their house stadium, the Los Angeles Rams will start protection of their title on Thursday, Sept. 8 after they host one other Super Bowl contender, the Buffalo Bills, within the 2022 NFL Kickoff Sport. After beating the Bengals within the Tremendous Bowl, the Rams added receiver Allen Robinson and linebacker Bobby Wagner within the offseason. They will face a Payments workforce that has received the AFC East the final two years. Kickoff is 8:20 p.m. ET. Buffalo is favored by 2.5 factors within the newest NFL odds from Caesars Sportsbook, whereas the over/beneath for complete factors scored is 52. The sport is considered one of 16 on a loaded Week 1 NFL schedule. Different key NFL matchups embrace the Cowboys and Buccaneers colliding in a rematch of final season’s NFL Kickoff Sport, and the BroncosRussell Wilson returning to Seattle to face his former workforce, the Seahawks. Earlier than you make any Week 1 NFL picks or NFL parlays, be sure you see the NFL predictions and betting advice from SportsLine’s proven computer model.

The mannequin, which simulates each NFL recreation 10,000 instances, is up over $7,500 for $100 gamers on top-rated NFL picks since its inception. The mannequin enters the 2022 NFL season on an unbelievable 138-97 run on top-rated NFL picks that dates again to the 2017 season. Amazingly, it hasn’t missed a top-rated decide since Week 15 final season. 

The mannequin additionally ranked within the prime 10 on NFLPickWatch 4 of the previous six years on straight-up NFL picks and beat greater than 94 % of CBS Sports activities Soccer Choose’em gamers 4 instances throughout that span. Anybody who has adopted it’s manner up.

Now, the mannequin has locked in 5 assured NFL greatest bets for Week 1. Should you efficiently parlay its picks, you would be taking a look at an enormous payout of round 25-1. You can only see the model’s Week 1 NFL picks at SportsLine

Prime Week 1 NFL picks

After simulating each recreation 10,000 instances, the mannequin is excessive on the Indianapolis Colts to cowl as eight-point highway favorites in opposition to the Houston Texans. Indianapolis is coming off a 9-8 season through which the workforce barely missed the playoffs. Houston was as soon as once more one of many worst groups within the NFL, going 4-13. After the season, coach David Culley was fired and changed by Lovie Smith.

The Colts have dominated the season collection not too long ago between the groups. Indianapolis has received the final 4 video games, six of the final seven and eight of the final 10. The Colts’ common margin of victory throughout the four-game profitable streak is 28, and so they received the 2 matchups final yr by 28 and 31 factors. See which other NFL parlay picks to make here.

How one can make Week 1 NFL parlays

The mannequin additionally jumped on 4 different NFL matchups the place it says the road is manner off, together with an underdog that wins outright. You can only see the model’s NFL Week 1 best bets and parlay at SportsLine

What are the mannequin’s prime Week 1 NFL picks? And which different NFL matchups must you goal for a robust 25-1 payout? Visit SportsLine now to see the Week 1 NFL best bets from a model on a 138-97 run on its top-rated picks, and discover out.

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